Acute and chronic infections with nonprimate hepacivirus in young horses
نویسندگان
چکیده
منابع مشابه
Acute and chronic infections with nonprimate hepacivirus in young horses
The recently discovered nonprimate hepacivirus (NPHV) naturally infects horses and is the closest known homolog of hepatitis C virus to date. Within a follow-up study acute field infections were monitored in four young Thoroughbred horses until the ages of 12-13 months. Serum samples were analyzed for the presence of NPHV RNA and anti-NPHV NS3 antibodies and liver specific parameters were evalu...
متن کاملNonprimate Hepaciviruses in Domestic Horses, United Kingdom
Although the origin of hepatitis C virus infections in humans remains undetermined, a close homolog of this virus, termed canine hepacivirus (CHV) and found in respiratory secretions of dogs, provides evidence for a wider distribution of hepaciviruses in mammals. We determined frequencies of active infection among dogs and other mammals in the United Kingdom. Samples from dogs (46 respiratory, ...
متن کاملCharacterization of nonprimate hepacivirus and construction of a functional molecular clone.
Nonprimate hepacivirus (NPHV) is the closest known relative of hepatitis C virus (HCV) and its study could enrich our understanding of HCV evolution, immunity, and pathogenesis. High seropositivity is found in horses worldwide with ∼ 3% viremic. NPHV natural history and molecular virology remain largely unexplored, however. Here, we show that NPHV, like HCV, can cause persistent infection for o...
متن کاملSeroepidemiology of non-primate hepacivirus (NPHV) in Japanese native horses
Non-primate hepacivirus (NPHV) is recently identified as a closely related homologue of hepatitis C virus. The previous studies showed a high prevalence of NPHV infection among Japanese domestic horses originated from abroad. The historical distribution of NPHV among horses in Japan, therefore, is still unknown. In this study, seroepidemiological study of NPHV was conducted using 335 sera from ...
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ژورنال
عنوان ژورنال: Veterinary Research
سال: 2016
ISSN: 1297-9716
DOI: 10.1186/s13567-016-0381-6